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Steps:
1. Download and install from Apple XCode Command Line utilities
2. Download and install MacPorts from MacPorts.org
3. Options: I downloaded and installed 'wine' from Winehq.org and am using it. MacPorts also has a port of 'wine' that can be downloaded and installed. I have not used the MacPort-wine software.
4. Using MacPorts install cabextract .
5. Download and install 'winetricks'. Use winetricks to install dotnet45
6. Download freescan and install freescan using 'wine'
Once I did the about freescan ran fine on the Mac. However, to communicate with the scanner over the USB port I had to run 'wine regedit' and create a string entry in HKEY_Local_Software_wine_ports for the KEY: COM1 and the VALUE: <fullpath to the device file for the usbmodem> ...in my case /dev/tty.usbmodem14201. As the path seems to change each time you connect the scanner to the Mac, this, for now, has to be done each time before starting freescan. I'm sure there is a way around this -- just haven't worked on finding it yet.
Bottom line is FreeSCAN will run on the Mac without any emulator, or paying for a version of windows, etc.
Details for each of the steps above are found by GOOGLING the software and searching within the hits.
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Mac Document Scanning Software

Epson Connect Printer Setup for Mac
Follow the steps below to enable Epson Connect for your Epson printer on a Mac.
Important: Your product needs to be set up with a network connection before it can be set up with Epson Connect. If you need to set up the connection, see the Start Here sheet for your product for instructions. To see the sheet, go to the Epson support main page, select your product, Manuals and Warranty, then Start Here.
Document Scanner Software For Mac
- Download and run the Epson Connect Printer Setup Utility.
- Click Continue.
- Agree to the Software License Agreement by clicking Continue, and then Agree.
- Click Install, and then click Close.
- Select your product, and then click Next.
Note: If the window doesn't automatically appear, open a Finder window and select Application > Epson Software, and then double-click Epson Connect Printer Setup. - Select Printer Registration, and then click Next.
- When you see the Register a printer to Epson Connect message, click OK.
- Scroll down, click the I accept the Terms and Conditions check box, and then click Next.
- Do one of the following:
- If you're creating a new account, fill out the Create An Epson Connect Account form, then click Finish.
- If you're registering a new product with an existing account, click I already have an account, fill out the Add a new printer form, and then click Add.
- Click Close.
- See our Activate Scan To Cloud and Remote Print instructions to activate the Scan to Cloud and Remote Print services.